Abstract #1853

Quantification of Relative Cerebral Blood Volume in Aging Collapsin Response Mediator Protein 1 Gene Knockout Mice

Tzu-Ming Hung¹, Sheng-Min Huang², Yun-Chieh Tsai³, Ting-Yu Chin⁴, and Hsu-Hsia Peng¹

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Institute of biomedical engineering and nanomedicine, National Health Research Institutes, Miaoli, Taiwan, ³Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ⁴Department of Bioscience Technology, Chung Yuan Christian University, Taoyuan, Taiwan

Mice deficient of collapsin response mediator protein 1 (CRMP-1) gene may cause neural disorganization in hippocampus and demonstrate memory and spatial learning dysfunction. Relative cerebral blood volume (rCBV) can reflect the blood volume within the tissue and was served as an index to correlate with psychosis progression. The purpose of this study was to quantify the rCBV of hippocampus and to explore the difference of vascular distribution in wild type (WT) and aging CRMP-1 knockout (KO) mice. KO mice possessed significantly higher rCBV in the hippocampus than WT mice, indicating the increased blood volume in the hippocampus of KO mice.

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