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Abstract #1855

An increased Normal Appearing White Matter perfusion: a possible radiological inflammatory marker in relapsing-remitting multiple sclerosis

Caterina Lapucci1,2, Marco Fiorelli3, Annunziata Stefanile4, Silvana Zannino4, Maria Maddalena Filippi5, Antonio Cortese3, Carlo Piantadosi6, Marco Salvetti7, Matilde Inglese1,8, and Tatiana Koudriavtseva4
1DINOGMI, University of Genoa, Genoa, Italy, 2Department of Experimental Neurosciences, Ospedale Policlinico San Martino IRCCS, Genoa, Italy, 3Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy, Rome, Italy, 4Department of Clinical Experimental Oncology, IRCCS Regina Elena National Cancer Institute, IFO, Rome, Italy, Rome, Italy, 5Fatebenefratelli Foundation, Afar Division, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy, Rome, Italy, 6Neurology Unit, San Giovanni-Addolorata Hospital, Rome, Italy, Rome, Italy, 7Department Of Neuroscience Mental Health And Sensory Organs (NEMOS), Sapienza University, Sant’Andrea Hospital, Rome, Italy, Rome, Italy, 8Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA/, New York, NY, United States

Hemodynamic changes by Dynamic Susceptibility Contrast enhanced perfusion (DSC) in Multiple Sclerosis (MS) have been poorly evaluated. The aim of the study was to compare relapsing and remitting (RR) MS patients by DSC. 45 RRMS patients, 22 with (REL) and 23 without (REM) relapse in the previous 2 months were included. A hyperperfusion of the Normal Appearing White Matter (NAWM) compared to FLAIR lesions was noted. The correlations between NAWM perfusion, disease duration and 1-year before Annualized Relapse Rate in REM patients seemed to suggest that an increased NAWM perfusion may be a radiological marker of higher inflammatory activity.

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