Abstract #1855

An increased Normal Appearing White Matter perfusion: a possible radiological inflammatory marker in relapsing-remitting multiple sclerosis

Caterina Lapucci^1,2, Marco Fiorelli³, Annunziata Stefanile⁴, Silvana Zannino⁴, Maria Maddalena Filippi⁵, Antonio Cortese³, Carlo Piantadosi⁶, Marco Salvetti⁷, Matilde Inglese^1,8, and Tatiana Koudriavtseva⁴

¹DINOGMI, University of Genoa, Genoa, Italy, ²Department of Experimental Neurosciences, Ospedale Policlinico San Martino IRCCS, Genoa, Italy, ³Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy, Rome, Italy, ⁴Department of Clinical Experimental Oncology, IRCCS Regina Elena National Cancer Institute, IFO, Rome, Italy, Rome, Italy, ⁵Fatebenefratelli Foundation, Afar Division, Fatebenefratelli Hospital, Isola Tiberina, Rome, Italy, Rome, Italy, ⁶Neurology Unit, San Giovanni-Addolorata Hospital, Rome, Italy, Rome, Italy, ⁷Department Of Neuroscience Mental Health And Sensory Organs (NEMOS), Sapienza University, Sant’Andrea Hospital, Rome, Italy, Rome, Italy, ⁸Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA/, New York, NY, United States

Hemodynamic changes by Dynamic Susceptibility Contrast enhanced perfusion (DSC) in Multiple Sclerosis (MS) have been poorly evaluated. The aim of the study was to compare relapsing and remitting (RR) MS patients by DSC. 45 RRMS patients, 22 with (REL) and 23 without (REM) relapse in the previous 2 months were included. A hyperperfusion of the Normal Appearing White Matter (NAWM) compared to FLAIR lesions was noted. The correlations between NAWM perfusion, disease duration and 1-year before Annualized Relapse Rate in REM patients seemed to suggest that an increased NAWM perfusion may be a radiological marker of higher inflammatory activity.

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