Abstract #1876

T2 Quantification in Liver Iron Overload Using RF Phase Modulated Gradient Echo MRI

Ruvini Navaratna^1,2, Daiki Tamada², Gregory Simchick², Diego Hernando^1,2, and Scott B Reeder^1,2,3,4,5

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Radiology, University of Wisconsin - Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ⁴Medicine, University of Wisconsin - Madison, Madison, WI, United States, ⁵Emergency Medicine, University of Wisconsin - Madison, Madison, WI, United States

MR-based relaxation parameters such as T2 are sensitive to iron content in the liver. Unfortunately, current T2 mapping techniques often suffer from long acquisition times. A recently introduced phase-based T2 mapping technique shows promise for rapid liver T2 quantification within a single breath-hold. However, its ability to quantify short T2 in liver iron overload is unknown. In this work, we present a modified 3D phase-based T2 mapping method for quantifying short T2 values encountered in liver iron overload. Our results demonstrate preliminary feasibility of phase-based RF modulated GRE to map short T2 values rapidly and accurately.

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