Abstract #1882

Non-Alcoholic Fatty Liver Disease: Association Between the Biomechanics and Inflammation Severity in Early-Stage Diffuse Liver Disease

Christian Simonsson^1,2, Markus Karlsson¹, Patrik Nasr³, Ralph Sinkus⁴, Simone Ignatova⁵, Nils Dahlström¹, Mattias Ekstedt^2,3, Stergios Kechagias³, and Peter Lundberg^1,2

¹Department of Radiation Physics, Radiology, Linköping University, Linköping, Sweden, ²Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, ³Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, ⁴Imaging Sciences & Biomedical Engineering, Kings College London,, London, United Kingdom, ⁵Linköping University, Linköping, Sweden

With the high prevalence of non-alcoholic fatty liver disease (NAFLD), it is important to have precise and non-invasive clinical methods to detect early stages of non-alcoholic steatohepatitis (NASH) and fibrosis progression. It has recently been shown that 3D Magnetic resonance elastography (3D-MRE) could be used to measure inflammation in the liver. To this cause, we investigated the association between liver 3D-MRE biomechanical properties and histopathological features in a liver study cohort of 25 patients including individuals with NASH. We here show that 3D-MRE biomechanical biomarkers show a correlation with higher degrees of hepatic inflammation in this cohort.

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