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Abstract #1882

Non-Alcoholic Fatty Liver Disease: Association Between the Biomechanics and Inflammation Severity in Early-Stage Diffuse Liver Disease

Christian Simonsson1,2, Markus Karlsson1, Patrik Nasr3, Ralph Sinkus4, Simone Ignatova5, Nils Dahlström1, Mattias Ekstedt2,3, Stergios Kechagias3, and Peter Lundberg1,2
1Department of Radiation Physics, Radiology, Linköping University, Linköping, Sweden, 2Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden, 3Department of Medical and Health Sciences, Linköping University, Linköping, Sweden, 4Imaging Sciences & Biomedical Engineering, Kings College London,, London, United Kingdom, 5Linköping University, Linköping, Sweden

With the high prevalence of non-alcoholic fatty liver disease (NAFLD), it is important to have precise and non-invasive clinical methods to detect early stages of non-alcoholic steatohepatitis (NASH) and fibrosis progression. It has recently been shown that 3D Magnetic resonance elastography (3D-MRE) could be used to measure inflammation in the liver. To this cause, we investigated the association between liver 3D-MRE biomechanical properties and histopathological features in a liver study cohort of 25 patients including individuals with NASH. We here show that 3D-MRE biomechanical biomarkers show a correlation with higher degrees of hepatic inflammation in this cohort.

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