Abstract #1886

MRI Characterisation of the Reformation of Colonic Content after Bowel Purgation

Hannah Grace Williams^1,2, Caroline Hoad^1,3, Neele Dellschaft^1,3, Christabella Ng^3,4, Alan Smyth^3,4, Giles Major^2,3, and Penny Gowland^1,3

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²Nottingham Digestive Diseases Centre, University of Nottingham, Nottingham, United Kingdom, ³National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom, ⁴Division of Child Health, Obstetrics and Gynaecology, University of Nottingham, Nottingham, United Kingdom

A key colonic function is the formation of faeces and the growth and proliferation of the microbiota. This process is little described as it is difficult to study in vivo. We aimed to investigate it using MRI which can non-invasively monitor changes in the colonic content. In 8 healthy volunteers we observed the initial process of faecal formation following purgation. The results suggest that MRI can provide new insights into the important physiological process of faeces formation and establishment of the microbiome in the colon.

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