Intestinal gas in upper abdomen interferes with diffusion-weighted image. Echo-planar imaging with compressed SENSE (EPICS) can reduce the susceptibility artifacts by shortening the data sampling time. In this study, EPICS and conventional SENSE-DWI were compared visually and quantitatively. The visual score of EPICS were significantly higher than that of SENSE in the pancreatic head and body. The signal ratio between the pancreas and spinal cord was significantly higher in the pancreatic tail in SENSE. The ADC value of EPICS was significantly higher in the pancreatic head. EPICS is feasible for reducing gas-producing artifact in the upper abdomen.