Abstract #1910

Microvascular MRI Signal Changes in the Presence of Amyloid-Beta Plaques or Microbleeds: A Simulation Study

Geon-Ho Jahng^1,2, Chang Hyun Yoo³, Seokha Jin⁴, DongKyu Lee⁴, and HyungJoon Cho⁴

¹Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ²Medicine, Kyung Hee University, Seoul, Korea, Republic of, ³Physics, Kyung Hee University, Seoul, Korea, Republic of, ⁴Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of

We simulated the changes in microvascular (MV) MRI signals with and without existing amyloid-beta plaques or microbleeds in an imaging voxel. The Monte Carlo simulations with the finite perturber method were used to calculate MV indices of mean vessel diameter (mVD), vessel size index (VSI), mean vessel density (Q), blood volume fraction (BVf), and microvessel-weighted imaging (MvWI). The simulation was performed with three different voxel environmental conditions: only the MV structures, MV structures with amyloid-beta plaques, and MV structures with microbleeds.

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