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Abstract #1943

Maturation and degeneration of the human cerebrum across the adult lifespan

Matthew Kiely1, Nikkita Khattar1, Curtis Triebswetter1, Zhaoyuan Gong1, Maryam H. Alsameen1, Richard G. Spencer1, and Mustapha Bouhrara1
1Laboratory of Clinical Investigation, National Institute on Aging, Baltimore, MD, United States

Using myelin water fraction (MWF) and DTI, we investigated age- and sex-related differences in brain maturation and degeneration in a large cohort of unimpaired participants. We observed quadratic relationships between MWF or DTI indices and age, suggesting that brain maturation continues until middle age followed by a phase of rapid degeneration afterward. Sexual dimorphism in these processes was not significant in most cerebral regions studied. Finally, we observed weak-to-moderate correlations between DTI indices and MWF indicating that these indices could not serve as proxies of myelin content while highlighting the value of using multiple quantitative MRI metrics in clinical investigation.

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