Late-onset GM2-Gangliosidoses (LOGG) are rare lysosomal storage disorders with slowly progressing neurological symptoms that encompass late-onset Tay-Sachs disease (LOTS) and Sandhoff disease (LOSD). We performed sMRI-MRS to discern how cerebellar aberrations may relate to underlying metabolic abnormalities, and their relationships to clinical presentations. Results revealed that structural and metabolic differences between LOTS patients and controls were more prominent than the collective group of LOGG patients vs. controls. Significant clinical associations with imaging-markers also differed when LOTS patients were analyzed separately versus in conjunction with LOSD patients. While LOSD could not be accurately assessed, it appeared to be distinct from LOTS.