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Abstract #2004

ProFit-v3: accuracy and precision evaluation of a new spectral fitting software

Tamas Borbath1,2, Saipavitra Murali-Manohar1,2, Johanna Dorst1,3, Andrew Martin Wright1,3, and Anke Henning1,4
1High-field Magnetic Resonance, Max Planck Institute for biological Cybernetics, Tübingen, Germany, 2Faculty of Science, University of Tübingen, Tübingen, Germany, 3IMPRS for Cognitive & Systems Neuroscience, Tübingen, Germany, 4Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

In this work, we present the newly developed MRS fitting software ProFit-v3, including adaptive baseline stiffness control and a newly proposed cost function calculation. ProFit-v3 was evaluated for accuracy and precision using both simulated and in vivo spectra, and the results were compared against LCModel. The adaptive spline baseline model of ProFit-v3 modelled different simulated baseline distortions well. The fitting accuracy measured on simulated data was slightly better for ProFit-v3 than for LCModel. While the fitting precision of ProFit-v3 was comparable to that of LCModel for the simulated data, LCModel proved to be somewhat more precise for in vivo spectra.

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