Abstract #2021

On the quantification of the striatum neurochemical profile using STEAM MRS: a comparison of 3T versus 7T in a cohort of elderly subjects

Ana Gogishvili^1,2, Christopher E. J. Doppler^3,4, Ezequiel Farrher¹, Aline Seger^3,4, Michael Sommerauer^3,4, Ketevan Kotetishvili², and N. Jon Shah^1,5,6,7

¹Institute of Neuroscience and Medicine 4, Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany, ²Engineering Physics Department, Georgian Technical University, Tbilisi, Georgia, ³Institute of Neuroscience and Medicine 3, Forschungszentrum Jülich, Jülich, Germany, ⁴University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, Cologne, Germany, ⁵Institute of Neuroscience and Medicine 11, Forschungszentrum Jülich, Jülich, Germany, ⁶JARA BRAIN Translational Medicine, RWTH Aachen University, Aachen, Germany, ⁷Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany

The primary aim of this study is to quantify the neurochemical profile of the human striatum in vivo in healthy subjects, using data acquired with a single voxel STEAM MRS sequence at 3T and 7T in a case-control study on Parkinson’s disease. Given that the voxel sizes at both fields were different, we intend to ascertain the conditions under which the neurochemical profiles at 3T and 7T are comparable. To this end, we assessed different quantification methods and strategies, including correction for transverse and longitudinal relaxation and for differences in grey and white matter metabolite concentrations.

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