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Abstract #2021

On the quantification of the striatum neurochemical profile using STEAM MRS: a comparison of 3T versus 7T in a cohort of elderly subjects

Ana Gogishvili1,2, Christopher E. J. Doppler3,4, Ezequiel Farrher1, Aline Seger3,4, Michael Sommerauer3,4, Ketevan Kotetishvili2, and N. Jon Shah1,5,6,7
1Institute of Neuroscience and Medicine 4, Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany, 2Engineering Physics Department, Georgian Technical University, Tbilisi, Georgia, 3Institute of Neuroscience and Medicine 3, Forschungszentrum Jülich, Jülich, Germany, 4University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, Cologne, Germany, 5Institute of Neuroscience and Medicine 11, Forschungszentrum Jülich, Jülich, Germany, 6JARA BRAIN Translational Medicine, RWTH Aachen University, Aachen, Germany, 7Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany

The primary aim of this study is to quantify the neurochemical profile of the human striatum in vivo in healthy subjects, using data acquired with a single voxel STEAM MRS sequence at 3T and 7T in a case-control study on Parkinson’s disease. Given that the voxel sizes at both fields were different, we intend to ascertain the conditions under which the neurochemical profiles at 3T and 7T are comparable. To this end, we assessed different quantification methods and strategies, including correction for transverse and longitudinal relaxation and for differences in grey and white matter metabolite concentrations.

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