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Abstract #2036

Selective microstructure-size filters for non-invasive quantitative MRI

Milena Capiglioni1,2,3, Analía Zwick1, Pablo Jimenez1, and Gonzalo Álvarez1,2
1Laboratorio de Espectroscopía e Imágenes por RMN, Departamento de Física Médica, Centro Atómico Bariloche - CNEA - CONICET, Bariloche, Argentina, 2Instituto Balseiro, CNEA, Universidad Nacional de Cuyo, Bariloche, Argentina, 3Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, University Hospital of Bern, University of Bern, Bern, Switzerland

Extracting quantitative microstructure information of living-tissue by non-invasive imaging is an outstanding challenge for understanding disease mechanisms. We introduce a method to make selectively images of microstructure-sizes by probing molecule diffusion with MRI. It relies on designing dynamical control of nuclear spins to sense magnetization “decay-shifts” rather than the commonly used spin-echo decay-rates. The feasibility and performance of the method are illustrated with proof-of-principle experiments and simulations on typical size-distributions of white-matter in the mouse brain. These results position spin-echo decay-shifts as a promising MRI tool to perform non-invasive histology without assuming a microstructure distribution model.

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