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Abstract #2108

MR Elastography-based Shear Strain Mapping for Assessment of Microvascular Invasion in Hepatocellular Carcinoma

Bing Hu1, Ziying Yin2, Mengsi Li1, Ying Deng1, Sichi Kuang1, Jun Chen2, Linqi Zhang1, Meng Yin2, Kevin J. Glaser2, Richard L. Ehman2, and Jin Wang1
1Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, 2Radiology, Mayo Clinic, Rochester, MN, United States

The presence of microvascular invastion (MVI) at histopathology is an important predictive factor in managing hepatocellular carcinoma (HCC). We evaluated the potential of MRE-based shear strain mapping to assess adhesion characteristics at tumor boundaries and to non-invasively predict the presence of MVI. We retrospectively calculated maps displaying octahedral shear strain in exams of 61 HCC patients who underwent 3D multi-frequency MRE examinations. Results demonstrated that the prevalence of adherent tumor-liver parenchyma interface in positive MVI groups was significantly higher than negative groups. The results provide evidence that MRE-based shear strain mapping is helpful for non-invasive prediction of MVI in HCC.

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