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Abstract #2110

Correlation of functional MRI with changes in tumor microenvironment following sorafenib and immunotherapy in hepatocellular carcinoma

Yanqiao Ren1, Jingjie Yan2, Lian Yang1, Qingjia Bao3, Chaoyang Liu3, and Chuansheng Zheng1
1Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China, Wuhan, China, 2Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, 430074, China., Wuhan, China, 3State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathmatics, Innovation Academy for Precision Measurement Science and Technology, 430071Wuhan, China, Wuhan, China

Molecular and pathological characteristics of the tumor microenvironment have been shown to cause tumor heterogeneity and variability in therapeutic responses. We used functional MRI to evaluate the changes in tumor microenvironment after treatment with sorafenib and anti-PD-L1 antibody for hepatocellular carcinoma (HCC). The results indicated that DWI-MRI and MRS could dynamically assess microenvironmental changes including tumor necrosis and tumor hypoxia. The findings of this study are conducive to the establishment of an accurate correlation between imaging features-microenvironment characteristics-tumor anti-vascular treatment and immunotherapy, and the realization of scientific and precise individualized treatment of HCC.

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