Temporal diffusion spectroscopy using oscillating encoding gradients enables assessing tissue microstructure at a user-selected, arbitrary spatial scale. It has been demonstrated that this method is feasible with OGSE-EPI sequence. To study its robustness an OGSE-EPI sequence was implemented and repeatability and signal to noise ratio were assessed with two radiofrequency hardware setups and with or without respiratory gating. The effect of OGSE frequency was assessed for the pure diffusion coefficient (D) and for the apparent diffusion coefficient (ADC). Using a 4-channel surface coil and respiratory gating when measuring ADC at 100 Hz, the optimal repeatability coefficient (28%) was obtained.
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