Abstract #2137

Detection of liver fibrosis in a Rat NASH Model using water specific T1 mapping with Gadoxetic Acid -enhanced MRI

Qian Wan^1,2, Hao Peng ¹, Jianxun Lyu^1,2, Xiaoyi Liu³, Chuanli Cheng¹, Feng Liu³, Yangzi Qiao¹, Hairong Zheng¹, Xin Liu¹, Yi Wang³, and Chao Zou¹

¹Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Shenzhen College of Advanced Technology,University of Chinese Academy of Sciences, Shenzhen, China, ³Peking University People's Hospital, Beijing, China

The severity of live fibrosis is one of the most important prognostic factors for the long-term outcomes of Nonalcoholic steatohepatitis (NASH). Early and precise diagnosis is of crucial importance for the disease management of NASH patients. In this work, we detected the liver fibrosis using water specific T1 mapping with Gadoxetic Acid -enhanced MRI in a rat NASH model induced by methionine-choline deficient (MCD) diet. The study revealed that the reduction rates of water-T1 relaxation time before and after Gd-EOB-DTPA administration might be a useful tool to stage the mild and moderate live fibrosis in rat NASH model.

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