Abstract #2155

Reusable 3D printed enclosure with integrated cutting guides for the alignment of ex-vivo MRI with ex-vivo gross brain photographs

Nadim Farhat¹, Julia Kofler^2,3, Jacob Berardinelli¹, Mark Stauffer⁴, Tales Santini¹, Neilesh Vinjamuri¹, Andrea Sajewski ¹, Salem Alkhateeb¹, Tiago Martins¹, Noah Schweitzer ¹, Milos Ikonomovic^3,5, Howard J. Aizenstein^1,6, and Tamer S Ibrahim^1,6,7

¹Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States, ²Pathology, UPMC, Pittsburgh, PA, United States, ³Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Pathology, University of Pittsburgh, Pittsburgh, PA, United States, ⁵Neurology, University of Pittsburgh, Pittsburgh, PA, United States, ⁶Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States, ⁷Radiology, University of Pittsburgh, Pittsburgh, PA, United States

In this project, we implemented a novel approach to align ex-vivo MRI brain images and gross neuropathology photographs with minimal image processing. The approach included the design and implementation of a reusable 3D printed enclosure with integrated cutting guides . Our results show a good alignment between ex-vivo high field MRI and gross brain image photographs.

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