The sensitivity of different structural MRI sequences for the detection of clinical abnormalities in cross-sectional studies was evaluated using actual population studies. We studied 3 patient cohorts on two MRI scanners (1.5T and 3T), using T1wSE, T2wSE, T1GRE, T2SPACE and MTC sequences for clinical group comparisons. Novel insights into their clinical potential of different structural MRI scans indicated T1wSE and T2wSE offer advanced sensitivity and should be standard in clinical cross-sectional studies. . Although our sensitivity metric was computed for separate voxels, we expect inter-subject variance will have a similar effect on the sensitivity for cluster detection.
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