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Abstract #2168

Using an ANN to estimate Initial Values for Mapping of the Oxygen Extraction Fraction with combined QSM and qBOLD

Patrick Kinz1, Sebastian Thomas1, and Lothar R. Schad1
1Computer Assisted Clinical Medicine, Heidelberg University, Medical Faculty Mannheim, Mannheim, Germany

MRI-based mapping of oxygen extraction fraction with QSM and qBOLD is a non-invasive diagnostic tool with many possible applications. But current reconstruction methods based on quasi-Newton (QN) methods are very dependent on accurate parameter initialization. We compare the standard QN method with a clustering approach, and with a new initialization method in form of an ANN, which we previously developed to replace QN. This leads to reconstructed images with much less noise, compared to the direct output of the ANN and keeps the effect of reduced intersubject variability.

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