Abstract #2241

Relationship between brain temperature and prognosis during hypothermia in newborns with hypoxic-ischemic encephalopathy

Moyoko Tomiyasu^1,2, Jun Shibasaki³, Yasuhiko Terada⁴, Katsuaki Toyoshima³, Tatsuya Higashi¹, Takayuki Obata¹, and Noriko Aida²

¹Department of Molecular Imaging and Theranostics, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan, ²Department of Radiology, Kanagawa Children’s Medical Center, Yokohama, Japan, ³Department of Neonatology, Kanagawa Children’s Medical Center, Yokohama, Japan, ⁴Institute of Applied Physics, University of Tsukuba, Tsukuba, Japan

We examined brain temperatures of 81 neonates with hypoxic-ischemic encephalopathy during and/or after hypothermia therapy. The brain temperature was obtained from magnetic resonance spectroscopy data (3T). The subjects also had a neurological developmental test at the age of 18–22 months, and were divided into favorable and adverse outcome groups. Brain temperatures for each outcome were significantly lower during hypothermia compared with those after hypothermia. Although the poor prognosis group tended to have a large dispersion of brain temperature after hypothermia, there was no significant difference in brain temperature between the favorable and adverse outcome groups.

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