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Abstract #2241

Relationship between brain temperature and prognosis during hypothermia in newborns with hypoxic-ischemic encephalopathy

Moyoko Tomiyasu1,2, Jun Shibasaki3, Yasuhiko Terada4, Katsuaki Toyoshima3, Tatsuya Higashi1, Takayuki Obata1, and Noriko Aida2
1Department of Molecular Imaging and Theranostics, National Institute for Quantum and Radiological Science and Technology, Chiba, Japan, 2Department of Radiology, Kanagawa Children’s Medical Center, Yokohama, Japan, 3Department of Neonatology, Kanagawa Children’s Medical Center, Yokohama, Japan, 4Institute of Applied Physics, University of Tsukuba, Tsukuba, Japan

We examined brain temperatures of 81 neonates with hypoxic-ischemic encephalopathy during and/or after hypothermia therapy. The brain temperature was obtained from magnetic resonance spectroscopy data (3T). The subjects also had a neurological developmental test at the age of 18–22 months, and were divided into favorable and adverse outcome groups. Brain temperatures for each outcome were significantly lower during hypothermia compared with those after hypothermia. Although the poor prognosis group tended to have a large dispersion of brain temperature after hypothermia, there was no significant difference in brain temperature between the favorable and adverse outcome groups.

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