Abstract #2251

Multivariate Associations Among Symptoms, Cognition, Behavior, and White Matter across ADHD and typically developing children

Xuan Bu^1,2, Yingxue Gao¹, Kaili Liang¹, Weijie Bao¹, Lu Lu¹, Ying Chen¹, Lanting Guo³, Qiyong Gong¹, Susumu Mori², and Xiaoqi Huang¹

¹Radiology Department, Sichuan University, Chengdu, China, ²The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Psychiatry Department, Sichuan University, Chengdu, China

In current study, we discovered several multivariate patterns of white matter properties linked to clinical symptoms, cognition and behavior across children with and without ADHD. Each dimension of phenotype was linked to a specific pattern of white matter microstructure alterations. Furthermore, these associations captured deviations between children with and without ADHD and displayed developmental effects. Together, these results suggest that complex ADHD phenotypes are associated with specific patterns of abnormal white matter microstructure during brain development.

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