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Abstract #2251

Multivariate Associations Among Symptoms, Cognition, Behavior, and White Matter across ADHD and typically developing children

Xuan Bu1,2, Yingxue Gao1, Kaili Liang1, Weijie Bao1, Lu Lu1, Ying Chen1, Lanting Guo3, Qiyong Gong1, Susumu Mori2, and Xiaoqi Huang1
1Radiology Department, Sichuan University, Chengdu, China, 2The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 3Psychiatry Department, Sichuan University, Chengdu, China

In current study, we discovered several multivariate patterns of white matter properties linked to clinical symptoms, cognition and behavior across children with and without ADHD. Each dimension of phenotype was linked to a specific pattern of white matter microstructure alterations. Furthermore, these associations captured deviations between children with and without ADHD and displayed developmental effects. Together, these results suggest that complex ADHD phenotypes are associated with specific patterns of abnormal white matter microstructure during brain development.

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