Abstract #2254

Orientation dependence of T2 in newborn white matter shows dipole-dipole interaction effects

Lara Bartels^1,2, Jonathan Doucette^1,2, Christoph Birkl^2,3,4, Yuting Zhang^5,6,7,8, Alexander Mark Weber^2,9, and Alexander Rauscher^1,2,9,10

¹Department of Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ²UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ³Department of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria, ⁴Department of Neurology, Medical University of Graz, Graz, Austria, ⁵Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, China, ⁶Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China, ⁷Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China, ⁸Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China, ⁹Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada, ¹⁰Department of Radiology, University of British Columbia, Vancouver, BC, Canada

In adult White Matter (WM), tissue orientation effects on $$$R_2$$$ are best described by diffusion within field inhomogeneities created by the myelin sheath. Here we studied how $$$R_2$$$ relaxation depends on white matter fibre orientation in the human newborn brain in vivo. We found that the orientation dependency is very different from adults and best described by a model of dipole-dipole interaction.

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