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Abstract #2254

Orientation dependence of T2 in newborn white matter shows dipole-dipole interaction effects

Lara Bartels1,2, Jonathan Doucette1,2, Christoph Birkl2,3,4, Yuting Zhang5,6,7,8, Alexander Mark Weber2,9, and Alexander Rauscher1,2,9,10
1Department of Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, 2UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, 3Department of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria, 4Department of Neurology, Medical University of Graz, Graz, Austria, 5Department of Radiology, Children's Hospital of Chongqing Medical University, Chongqing, China, 6Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Medical University, Chongqing, China, 7Key Laboratory of Pediatrics in Chongqing, Chongqing Medical University, Chongqing, China, 8Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China, 9Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada, 10Department of Radiology, University of British Columbia, Vancouver, BC, Canada

In adult White Matter (WM), tissue orientation effects on $$$R_2$$$ are best described by diffusion within field inhomogeneities created by the myelin sheath. Here we studied how $$$R_2$$$ relaxation depends on white matter fibre orientation in the human newborn brain in vivo. We found that the orientation dependency is very different from adults and best described by a model of dipole-dipole interaction.

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