2D GRE MRE liver images acquired at 4 transverse levels in breath-hold times >13s per slice is currently standard of care (SC_2D_4BH). Inadequate breath-holds lead to inaccurate stiffness estimation and/or failed studies. The combination of wave polarity-inversion motion encoding and compressed-SENSE enables MRE images to be acquired in less than half the breath-hold time (2D_CS_HBH) e.g. <7s, with identical spatial resolution and field of view. In 19 participants, mean liver shear stiffness values estimated with SC_2D_4BH and 2D_CS_HBH correlated very strongly (ICC>0.96) with a bias of <0.15 kPa (<6%). 2D_CS_HBH MRE is beneficial in participants with compromised breath-holding capacity.
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