Abstract #2327

Pseudo continuous arterial spin labeling perfusion MRI for predicting tumor response to neoadjuvant chemotherapy in advanced rectal cancer

Yoshihiko Fukukura¹, Yuichi Kumagae¹, Koji Takumi¹, Hiroaki Nagano¹, Masanori Nakajo¹, Kiyohisa Kamimura¹, Takashi Iwanaga², Yuta Akamine³, and Takashi Yoshiura¹

¹Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, ²Kagoshima University Hospital, Kagoshima, Japan, ³Philips Japan, Minatoku, Japan

This study focused on the feasibility of pseudo continuous arterial spin labeling (pCASL) perfusion MRI as a non-invasive tool for predicting the response of locally advanced rectal cancer treated with neoadjuvant chemotherapy in comparison with dynamic contrast-enhanced MRI and diffusion-weighted imaging. Our results showed blood flow derived from pCASL was significantly higher in responders than in non-responders. These results suggested the promise of pCASL as a non-invasive alternative to dynamic contrast-enhanced MRI for predicting the treatment response to NAC in locally advanced rectal cancer.

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