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Abstract #2327

Pseudo continuous arterial spin labeling perfusion MRI for predicting tumor response to neoadjuvant chemotherapy in  advanced rectal cancer

Yoshihiko Fukukura1, Yuichi Kumagae1, Koji Takumi1, Hiroaki Nagano1, Masanori Nakajo1, Kiyohisa Kamimura1, Takashi Iwanaga2, Yuta Akamine3, and Takashi Yoshiura1
1Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan, 2Kagoshima University Hospital, Kagoshima, Japan, 3Philips Japan, Minatoku, Japan

This study focused on the feasibility of pseudo continuous arterial spin labeling (pCASL) perfusion MRI as a non-invasive tool for predicting the response of locally advanced rectal cancer treated with neoadjuvant chemotherapy in comparison with dynamic contrast-enhanced MRI and diffusion-weighted imaging. Our results showed blood flow derived from pCASL was significantly higher in responders than in non-responders. These results suggested the promise of pCASL as a non-invasive alternative to dynamic contrast-enhanced MRI for predicting the treatment response to NAC in locally advanced rectal cancer.

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