Manual delineation of volume of interest (VOI) is widely used in current radiomics analysis, suffering from high variability. The purpose of our study was to investigate the effects of delineation of VOIs on radiomics analysis for the preoperative T staging based on high-resolution T2WI. The result demonstrated that differences in delineation of VOIs affected radiomics analysis, the minimum contour method has better stability in extracting features and the maximum contour method has better diagnostic efficiency in patients with rectal cancer.
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