Hepatocellular carcinoma (HCC) is the most common malignancy cancer and the second major contributor to cancer-related mortality worldwide. Diffusion-weighted imaging (DWI) has been widely used in HCC evaluation and showed great potential, while with some limitations like low SNRs and artifacts causing by high b values, and prolonged acquisition time. Synthetic DWI is mathematically derived from directly acquired DWI with at least two different b-values, which may tackle the limitations of conventional acquired DWI. This study aims to investigate the clinical feasibility and diagnosis performance of synthetic DWI in patients with HCC compared with conventional acquired DWI qualitatively and quantitatively.
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