Low frequency oscillations (LFOs) of cerebral vessels may be important indicators of aging and disease related changes to cerebral autoregulation and glymphatic clearance. Assessing LFOs during a vasodilatory stimulus, such as hypercapnia, may reveal age-associated changes not apparent at rest. This study utilized 3D radial sampling and local low-rank reconstruction of 4D flow MRI scans to achieve real time temporal resolution to assess LFOs. Preliminary results suggest that there were no hypercapnia or age-associated changes in LFOs in the large intracranial arteries; however, there were both age and hypercapnia effects on LFOs in the venous circulation.
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