Apparent exchange rate (AXR) mapping can be used to non-invasively investigate water exchange between the intra- and extracellular compartment, which might yield insight into cell membrane permeability. To obtain the AXR properly with the filter exchange imaging (FEXI) approach, signal stability is crucial. We show that electrocardiogram (ECG) triggering can lead to a slight improvement of the signal stability for AXR measurements in the human brain. However, pulsation-induced fluctuations are not the main source of signal variations. Thus, it remains questionable if investing additional measurement time in triggering is justified.
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