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Abstract #2462

Adequate mixing time for double diffusion encoding in normal brain structures and brain tumors

Kentaro Akazawa1, Koji Sakai1, Tomoaki Kitaguchi1, Tomonori Toyotsuji1, Thorsten Feiweier 2, Hiroshi Imai3, and Kei Yamada1
1Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan, 2Siemens Healthcare GmbH, Erlangen, Germany, 3Siemens Healthcare K.K., Shinagawa, Japan

The mixing time for double diffusion encoding (DDE) should be set low to reduce the relaxation effects but also high enough for estimating microscopic fractional anisotropy. We tested the adequacy of the mixing time of 30 msec by comparing acquisitions with parallel and anti-parallel directions as well as with orthogonal and collinear directions. Relatively short mixing time for our cohort was adequate to evaluate the microscopic fractional anisotropy not only in the normal brain area of the white matter and the central gray matter, but also in pathologically abnormal areas such as brain tumors.

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