Abstract #2474

Sensitivity to WM injury in SLE assessed by diffusion MRI: influence of field strength, acquisition approach and post-processing strategy

Evgenios N. Kornaropoulos^1,2, Stefan Winzeck^2,3, Theodor Rumetshofer¹, Anna Wikstrom¹, Linda Knutsson^4,5, Marta Correia⁶, Pia Sundgren^1,7,8, and Markus Nilsson¹

¹Diagnostic Radiology, Lund University, Lund, Sweden, ²Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom, ³Department of Computing, Imperial College London, London, United Kingdom, ⁴Department of Medical Radiation Physics, Lund University, Lund, Sweden, ⁵Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ⁶MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom, ⁷Lund University BioImaging Center, Lund University, Lund, Sweden, ⁸Department of Medical Imaging and Physiology, Skane University Hospital, Lund, Sweden

There are many ways to acquire and process diffusion MRI data. However, it is not known which yields the largest effect sizes in group studies. We evaluated the impact of different acquisitions (3T versus 7T and DTI versus DKI) and post-processing strategies (motion correction, Gibbs-ringing and denoising) on effect size estimates of white matter (WM) injury in patients with Systemic Lupus Erythematosus (SLE). Results showed that fractional anisotropy (FA) from a 3T DTI acquisition yielded the largest effect sizes.

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