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Abstract #2474

Sensitivity to WM injury in SLE assessed by diffusion MRI: influence of field strength, acquisition approach and post-processing strategy

Evgenios N. Kornaropoulos1,2, Stefan Winzeck2,3, Theodor Rumetshofer1, Anna Wikstrom1, Linda Knutsson4,5, Marta Correia6, Pia Sundgren1,7,8, and Markus Nilsson1
1Diagnostic Radiology, Lund University, Lund, Sweden, 2Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom, 3Department of Computing, Imperial College London, London, United Kingdom, 4Department of Medical Radiation Physics, Lund University, Lund, Sweden, 5Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 6MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, United Kingdom, 7Lund University BioImaging Center, Lund University, Lund, Sweden, 8Department of Medical Imaging and Physiology, Skane University Hospital, Lund, Sweden

There are many ways to acquire and process diffusion MRI data. However, it is not known which yields the largest effect sizes in group studies. We evaluated the impact of different acquisitions (3T versus 7T and DTI versus DKI) and post-processing strategies (motion correction, Gibbs-ringing and denoising) on effect size estimates of white matter (WM) injury in patients with Systemic Lupus Erythematosus (SLE). Results showed that fractional anisotropy (FA) from a 3T DTI acquisition yielded the largest effect sizes.

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