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Abstract #2503

Quantitative Comparison of 31P MRS Imaging Performances between 7T and 10.5T Human Scanners Using a Loop-dipole 31P-1H Probe

Xin Li1, Hannes M. Wiesner1, Matt Waks1, Xiao-Hong Zhu1, and Wei Chen1
1Center for magnetic Resonance Research (CMRR), Department of Radiology, University of Minnesota, Minneapolis, MN, United States

In vivo 31P MRS imaging (MRSI) is important for studying cerebral energy metabolism, intracellular NAD and redox ratio. However, it is challenging to achieve high spatiotemporal resolution owing to limited 31P sensitivity and low phosphorus metabolites concentration. We had demonstrated that ultrahigh field (UHF) could significantly improve the 31P-MRS sensitivity and spectral resolution. In this study, we designed and constructed a loop-dipole 31P-1H probe, which could operate at 7T and 10.5T for quantitative comparison of 31P MRSI signal-to-noise ratio (SNR) between the two fields. We found that the apparent SNR at 10.5T was significantly higher than that of 7T.

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