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Abstract #2520

Repeatability of multi-parametric renal MRI biomarkers in healthy subjects: An iBEAt pilot study

Kanishka Sharma1, Bashair Alhummiany2, David Shelley2,3, Margaret Saysell2,3, Maria-Alexandra Olaru4, Bernd Kühn4, Julie Bailey3, Kelly Wroe3, Cherry Coupland3, Michael Mansfield3, and Steven Sourbron1
1Department of Imaging, Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 2Department of Biomedical Imaging Sciences, University of Leeds, Leeds, United Kingdom, 3Leeds Teaching Hospitals, Leeds, United Kingdom, 4Siemens Healthcare GmbH, Erlangen, Germany

The iBEAt study MRI biomarker panel has been developed to determine if imaging biomarkers can improve predictions of renal function decline in diabetic kidney disease. The aim of this pilot study was to inform the approach to quality control and image processing of iBEAt data. Repeatability in 5 healthy volunteers (4 scans per subject) was analysed with a prototype image-processing pipeline. The results indicated that repeatability of renal T1, T2* and phase-contrast renal blood flow was comparable to literature, and measurement precision was sufficient to detect differences between volunteers. ASL had poor repeatability presumably from B0 inhomogeneities in labelling plane.

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