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Abstract #2522

Improved Accuracy of Ratiometric CEST pH Mapping using Two Iodinated Agents with Nonequivalent Amide Protons and a Single Low Saturation

Quan Tao1, Peiwei Yi1, Zimeng Cai1, Yingjie Mei2, Ruiyuan Liu1, and Yanqiu Feng1
1School of Biomedical Engineering, Southern Medical University, Guangzhou, China, 2Philips healthcare, Guangzhou, China

Various Iodinated agents were supposed to be pH sensors in kidney or tumor based on chemical exchange saturation transfer (CEST) mechanism. We compared different contrast agents (CAs) and their combination, established a ratiometric CEST pH imaging method to improve the accuracy of pH measurement in vivo, by combined the molar concentration ratio of two nonequivalent amide protons resonated at 4.3 ppm and 5.6 ppm.

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