Various Iodinated agents were supposed to be pH sensors in kidney or tumor based on chemical exchange saturation transfer (CEST) mechanism. We compared different contrast agents (CAs) and their combination, established a ratiometric CEST pH imaging method to improve the accuracy of pH measurement in vivo, by combined the molar concentration ratio of two nonequivalent amide protons resonated at 4.3 ppm and 5.6 ppm.
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