Abstract #2522

Improved Accuracy of Ratiometric CEST pH Mapping using Two Iodinated Agents with Nonequivalent Amide Protons and a Single Low Saturation

Quan Tao¹, Peiwei Yi¹, Zimeng Cai¹, Yingjie Mei², Ruiyuan Liu¹, and Yanqiu Feng¹

¹School of Biomedical Engineering, Southern Medical University, Guangzhou, China, ²Philips healthcare, Guangzhou, China

Various Iodinated agents were supposed to be pH sensors in kidney or tumor based on chemical exchange saturation transfer (CEST) mechanism. We compared different contrast agents (CAs) and their combination, established a ratiometric CEST pH imaging method to improve the accuracy of pH measurement in vivo, by combined the molar concentration ratio of two nonequivalent amide protons resonated at 4.3 ppm and 5.6 ppm.

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