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Abstract #2524

BOLD MRI for evaluating intra-renal oxygenation level during acute saline loading

El-Sayed H Ibrahim1, Abdul Parchur1, Srividya Kidambi1, Allen Cowley1, and Mingyu Liang1
1Medical College of Wisconsin, Milwaukee, WI, United States

Enhanced sensitivity of blood pressure to salt intake is observed in many hypertensive patients. The kidney plays a key role in the development of hypertension including salt-sensitive hypertension. In this study, we used BOLD MRI to examine the temporal response of renal medullary and cortical oxygenation levels during saline infusion in a small set of young subjects. The results showed that during the period of fast saline infusion, tissue oxygenation levels remained almost constant in the cortex but showed 10%-15% average reduction in the medulla. The responses, however, varied between subjects, which may reflect differences in salt-sensitive versus salt-insensitive individuals.

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