Abstract #2559

Quantitative Neuroimaging Study for a Non-human Primate Brain Infected with Intramuscular Ebola Virus

Byeong-Yeul Lee¹, Jeffrey M. Solomon², Marcelo Castro¹, Dong-Yun Kim³, Joseph Laux¹, Becky Reeder¹, Richard S. Bennett¹, Dima Hammoud^4,5, and Ji Hyun Lee¹

¹Integrated Research Facility at Fort Detrick, Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, United States, ²Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, United States, ³Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD, United States, ⁴Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, United States, ⁵Center for Infectious Disease Imaging, National Institutes of Health, Bethesda, MD, United States

The goal of this study was to perform quantitative neuroimaging of rhesus monkey brains following exposure with Ebola virus (EBOV) via the intramuscular route. Using a high-resolution T1 relaxometry technique, we observed a significant increase in T1 values in the late stage (days 5-7 post inoculation). The most affected regions included the prefrontal-basal ganglia-cerebella pathway. These results are suggestive of CNS involvement in EBOV and provide new insights into the underlying pathophysiology in the brain.

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