Abstract #2559

Quantitative Neuroimaging Study for a Non-human Primate Brain Infected with Intramuscular Ebola Virus

Byeong-Yeul Lee¹, Jeffrey M. Solomon², Marcelo Castro¹, Dong-Yun Kim³, Joseph Laux¹, Becky Reeder¹, Richard S. Bennett¹, Dima Hammoud^4,5, and Ji Hyun Lee¹

¹Integrated Research Facility at Fort Detrick, Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, United States, ²Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, United States, ³Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD, United States, ⁴Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, United States, ⁵Center for Infectious Disease Imaging, National Institutes of Health, Bethesda, MD, United States

The goal of this study was to perform quantitative neuroimaging of rhesus monkey brains following exposure with Ebola virus (EBOV) via the intramuscular route. Using a high-resolution T1 relaxometry technique, we observed a significant increase in T1 values in the late stage (days 5-7 post inoculation). The most affected regions included the prefrontal-basal ganglia-cerebella pathway. These results are suggestive of CNS involvement in EBOV and provide new insights into the underlying pathophysiology in the brain.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.