Abstract #2575

Inhomogeneous Magnetization Transfer (ihMT) MRI and Coherent Anti-stoke Raman Scattering (CARS) microscopy applied on LPC demyelinating model

Andreea Hertanu^1,2, Cem Karakus^3,4, Lucas Soustelle^1,2, Victor N. D. Carvalho^1,2,5, Gopal Varma⁶, David C. Alsop⁶, Bilal El Waly^3,4, Olivier M. Girard^1,2, Franck Debarbieux^3,4, and Guillaume Duhamel^1,2

¹Aix Marseille Univ, CNRS, CRMBM, Marseille, France, ²APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, ³Aix Marseille Univ, CNRS, INT, Marseille, France, ⁴Aix Marseille Univ, CNRS, CERIMED, Marseille, France, ⁵Aix Marseille Univ, CNRS, ICR, Marseille, France, ⁶Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Intoxication of oligodendrocytes with lysophosphatidylcholine (LPC) is a useful model for the study of focal demyelination and more recently, neuronal damage. We propose an ihMT-CARS analysis on a rodent model of LPC-induced demyelination and a quantitative (T₁, T₂ and T_1D, the dipolar relaxation time) characterization of the demyelinated area.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.