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Abstract #2575

Inhomogeneous Magnetization Transfer (ihMT) MRI and Coherent Anti-stoke Raman Scattering (CARS) microscopy applied on LPC demyelinating model

Andreea Hertanu1,2, Cem Karakus3,4, Lucas Soustelle1,2, Victor N. D. Carvalho1,2,5, Gopal Varma6, David C. Alsop6, Bilal El Waly3,4, Olivier M. Girard1,2, Franck Debarbieux3,4, and Guillaume Duhamel1,2
1Aix Marseille Univ, CNRS, CRMBM, Marseille, France, 2APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 3Aix Marseille Univ, CNRS, INT, Marseille, France, 4Aix Marseille Univ, CNRS, CERIMED, Marseille, France, 5Aix Marseille Univ, CNRS, ICR, Marseille, France, 6Division of MR Research, Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Intoxication of oligodendrocytes with lysophosphatidylcholine (LPC) is a useful model for the study of focal demyelination and more recently, neuronal damage. We propose an ihMT-CARS analysis on a rodent model of LPC-induced demyelination and a quantitative (T1, T2 and T1D, the dipolar relaxation time) characterization of the demyelinated area.

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