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Abstract #2578

Alterations in brain connectivity as duration of disease increases in Parkinson's disease.

Priyanka Bhat1, S Senthil Kumaran2, Achal K Srivastava1, and Vinay Goyal3
1Neurology, AIIMS, Delhi, India, 2Nuclear Magnetic Resonance, AIIMS, Delhi, India, 3Neurology, Medanta, The Medicity, Gurgaon, India

Parkinson’s disease (PD) is charcterized by progressive degenration of dopaminergic neurons in substantia nigra. This leads to motor symptoms like bradykinesia with rigidity and tremor. PD patients also experience difficulty in traversing through narrow spaces. Indicating towards altered motor execution and planning and decision making. This study was aimed thus to explore the progressively deteriorating brain connectivity in PD. Functional connectivity was observed to be altered with duration of disease.

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