The clinical use of chemical exchange saturation transfer (CEST) imaging is limited by its relatively long scan time, because it typically acquires multiple saturation image frames. Here, a novel auto-calibrated reconstruction method by joint k-space and image-space parallel imaging (KIPI) is proposed for faster CEST acquisition. By under-sampling CEST image frames with variable acceleration factors, KIPI allows an acceleration factor of up to 8-fold for acquiring source images, yielding a net speed-up of 6-fold in scan time, and produces image quality close to that of the ground truth.
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