Abstract #2601

Simultaneous Myelin Water, Magnetic Susceptibility, and Morphometry Analyses Using Magnetization-prepared Multiple Spoiled Gradient Echo

Hirohito Kan^1,2, Yuto Uchida³, Yoshino Ueki⁴, Satoshi Tsubokura⁵, Hiroshi Kunitomo⁵, Harumasa Kasai⁵, Noriyuki Matsukawa³, and Yuta Shibamoto²

¹Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan, ²Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, ³Department of Neurology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, ⁴Department of Rehabilitation Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, ⁵Department of Radiology, Nagoya City University Hospital, Nagoya, Japan

This study confirmed the feasibility of the simultaneous acquisition and voxel-based myelin water fraction (MWF), quantitative susceptibility mapping (QSM), and morphometry (VBM) analysis using magnetization-prepared multiple spoiled gradient echo (MP-mSPGR) sequence throughout comparisons with patients with Alzheimer’s disease and healthy control. As a result, the voxel-based MWF could detect demyelination in patients with AD. In contrast, there was not a significant change in susceptibility. This result suggested that the MWF depended on only the myelin content. The VBM analysis delineated the atrophy pattern of AD. The MP-mSPGR sequence is feasible for simultaneous MWF, QSM, and VBM analyses.

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