As genomic screening initiatives expand, pre-symptomatic identification of genetic risk of disease is increasingly common. For example, Geisinger’s Genomic Screening and Counseling program has identified carriers of rare variants associated with arrhythmogenic cardiomyopathy, but most have no clinical diagnosis. We explored whether myocardial T1 or T2 maps or synthetic extracellular volume (sECV) in these patients could assist in risk stratification by identifying pre-clinical myocardial abnormalities. We compared these quantitative measures to those of controls with a normal cardiac MRI. Native T1 was significantly elevated in asymptomatic variant carriers; however, T2, post-contrast T1, and sECV values were comparable.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords