We proposed a novel strategy to improve the temporal resolution and/or SNR efficiency of perfusion imaging using velocity-selective (VS) labeling, by purposely labeling spins within a narrow velocity band. This strategy allows faster recovery/refreshment of the magnetization of arterial spins for improved SNR efficiency and temporal resolution. A few implementation methods of such labeling strategy were explored, using modified Fourier-transform based VS inversion pulses. The SNR efficiency and achievable temporal resolution were examined by ASL signal modeling, demonstrating a good promise for ultra-fast perfusion imaging with high SNR efficiency.
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