Abstract #2684

A new method for mapping baseline cerebral oxygen metabolism using breath-hold calibrated fMRI

Michael Germuska¹, Rachael Stickland², Hannah Chandler³, and Richard Wise^3,4

¹School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom, ²Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United States, ³School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁴Department of Neurosciences, University of Chieti-Pescara, Chieti, Italy

We derive a new expression for the maximum BOLD signal (M) that includes a simple model of oxygen exchange. Using this new expression for M and Monte-Carlo simulations we show that the resting cerebral metabolic rate of oxygen consumption (CMRO₂) can be estimated from the resting perfusion (CBF) and maximum BOLD signal (M). The proposed method is demonstrated in-vivo using a repeated breath-holding protocol to measure M. This new gas-free method of estimating CMRO₂ offers a pragmatic approach for estimate cerebral oxygen consumption that is simple to perform and well tolerated.

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