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Abstract #2684

A new method for mapping baseline cerebral oxygen metabolism using breath-hold calibrated fMRI

Michael Germuska1, Rachael Stickland2, Hannah Chandler3, and Richard Wise3,4
1School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom, 2Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United States, 3School of Psychology, Cardiff University, Cardiff, United Kingdom, 4Department of Neurosciences, University of Chieti-Pescara, Chieti, Italy

We derive a new expression for the maximum BOLD signal (M) that includes a simple model of oxygen exchange. Using this new expression for M and Monte-Carlo simulations we show that the resting cerebral metabolic rate of oxygen consumption (CMRO2) can be estimated from the resting perfusion (CBF) and maximum BOLD signal (M). The proposed method is demonstrated in-vivo using a repeated breath-holding protocol to measure M. This new gas-free method of estimating CMRO2 offers a pragmatic approach for estimate cerebral oxygen consumption that is simple to perform and well tolerated.

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