Abstract #2684

A new method for mapping baseline cerebral oxygen metabolism using breath-hold calibrated fMRI

Michael Germuska¹, Rachael Stickland², Hannah Chandler³, and Richard Wise^3,4

¹School of Physics and Astronomy, Cardiff University, Cardiff, United Kingdom, ²Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, IL, United States, ³School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁴Department of Neurosciences, University of Chieti-Pescara, Chieti, Italy

We derive a new expression for the maximum BOLD signal (M) that includes a simple model of oxygen exchange. Using this new expression for M and Monte-Carlo simulations we show that the resting cerebral metabolic rate of oxygen consumption (CMRO₂) can be estimated from the resting perfusion (CBF) and maximum BOLD signal (M). The proposed method is demonstrated in-vivo using a repeated breath-holding protocol to measure M. This new gas-free method of estimating CMRO₂ offers a pragmatic approach for estimate cerebral oxygen consumption that is simple to perform and well tolerated.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.