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Abstract #2726

PCASL labeling efficiency measurement with B0 off-resonance compensation at 7T

Gael Saib1, Alan Koretsky1, and S Lalith Talagala2
1NINDS/LFMI, National Institutes of Health, Bethesda, MD, United States, 2NINDS/NMRF, National Institutes of Health, Bethesda, MD, United States

At 7T, it is known that B1+ and B0 inhomogeneities reduce the PCASL labeling efficiency. Further, the short T2 of blood also reduces the maximum blood labeling efficiency that can be achieved in practice. In this work, we employed a PCASL-prepared FLASH sequence to measure vessel-specific labeling efficiency of PCASL with B0 off-resonance correction. At 7T, experimental data indicates a maximal labeling efficiency of ~0.6. This study also shows that optimization of PCASL labeling efficiency is possible by tailoring the average gradient according to the blood velocity range and B1 at the feeding arteries.

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