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Abstract #2732

Reproducibility and repeatability of quantitative pCASL measurements in a 3D-printed perfusion phantom

Yiming Wang1, Limin Zhou1, Durga Udayakumar1,2, and Ananth J. Madhuranthakam1,2
1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

Arterial spin labelling (ASL) is a non-invasive and non-contrast perfusion imaging technique that can serve as an imaging biomarker to assess tissue blood flow characteristics. A perfusion phantom is valuable to evaluate newly developed ASL sequences, test consistency and to compare sequence reproducibility across various scanners. In this study, we performed a longitudinal assessment of the reproducibility and repeatability of perfusion measurement using 2D pCASL sequence with 20 PLDs over 5 weeks duration with a previously developed 3D printed perfusion phantom. Intra-class correlation coefficient (ICC) of measured perfusion and T1 are 0.96 and 0.94 respectively, indicating good reproducibility and repeatability.

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