Abstract #2735

Intrasession reliability of arterial spin labeled MRI measured perfusion in GBM at 3T

Limin Zhou¹, Yiming Wang¹, Marco Da Cunha Pinho^1,2, Edward Pan^3,4,5, Yin Xi^1,6, Joseph A Maldjian^1,2, and Ananth J Madhuranthakam^1,2

¹Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, DALLAS, TX, United States, ⁴Department of Neurological Surgery, University of Texas Southwestern Medical Center, DALLAS, TX, United States, ⁵Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, DALLAS, TX, United States, ⁶Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States

A 3D TSE using Cartesian acquisition with spiral profile reordering (CASPR) in combination with pseudo-continuous arterial spin labeling (pCASL) was developed to improve the robustness of ASL measured perfusion to increased B0 inhomogeneities in GBM patients. Previous results showed high intrasession reliability of this method in GBM patients. In this study, we compared the 3D TSE-CASPR measured perfusion with clinically available 3D GraSE at 3T. With 24 GBM imaging sessions, the results showed that 3D pCASL with TSE-CASPR is more robust to B0 inhomogeneities and has higher intrasession reliability than the clinical sequence, 3D pCASL with GraSE at 3T.

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