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Abstract #2754

Comparison of multi-echo Dixon andmulti-echo MRS sequences to quantify hepatic iron overload in rabbits with or without fatty liver

Zhao Fan yu1, Chen Yidi1, Zhang Huiting2, Stephan Kannengiesser3, and Long Liling1
1Radiology Department, The First Affiliated Hospital of Guangxi Medical University, Nanning, China, 2Siemens Healthcare Ltd, MR Scientific Marketing, Wuhan, China, 3Siemens Healthcare GmbH, MR Application Development, Erlangen, Germany

Feasibility and accuracy of confounder-corrected 3D multi-echo-Dixon (ME-Dixon) imaging and T2-corrected multi-echo single-voxel (HISTO) spectroscopy for the quantification of liver iron content at 3T MRI were investigated in rabbits with or without fatty liver, compared with conventional 2D multi-gradient-echo (2D GRE) imaging, using histopathology as a reference. The results showed that compared with HISTO (R2_water) method, the multi-echo Dixon (R2*) method was found to be superior for liver iron and fat evaluations. AUC calculations showed that both the ME-Dixon and 2D GRE values had high accuracy for diagnosing liver iron overload in the rabbit model for LICs up to 7mg/g.

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