Feasibility and accuracy of confounder-corrected 3D multi-echo-Dixon (ME-Dixon) imaging and T2-corrected multi-echo single-voxel (HISTO) spectroscopy for the quantification of liver iron content at 3T MRI were investigated in rabbits with or without fatty liver, compared with conventional 2D multi-gradient-echo (2D GRE) imaging, using histopathology as a reference. The results showed that compared with HISTO (R2_water) method, the multi-echo Dixon (R2*) method was found to be superior for liver iron and fat evaluations. AUC calculations showed that both the ME-Dixon and 2D GRE values had high accuracy for diagnosing liver iron overload in the rabbit model for LICs up to 7mg/g.
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