IVIM is reckoned as a valuable tool for non-invasive detection and evaluation of liver fibrosis staging. However, only more small b values used in one scan improve the diagnosis of liver fibrosis. In clinics, the different fibrosis stages overlap in the same inflammation level. However, both physiological expressions were different. To distinguish fibrosis from inflammation on images may help clinical diagnosis and provide more effective treatments for patients. Our study demonstrated that Dfast indeed had excellent discrimination ability of early liver fibrosis S1 and S2 in CHB patients with the same inflammation grade.