Acute cellular rejection (ACR) occurs in 10-40% patients following liver transplantation (LT). Diffusion kurtosis imaging (DKI) provides more information about microstructure than standard monoexponential diffusion method. We analyzed the whole-liver volume histogram metrics of D map, K map, and ADC map with comparison those of the ACR and non-ACR group. Statistical analysis shows that most metrics of D maps were significantly lower in the ACR group than those in the non-ACR group, while most metrics of K maps were significantly higher in the ACR group those in the non-ACR group. None of the metrics of ADC maps were significantly different.