Ultrahigh-b radial DWI (UHb-rDWI) is an MRI technique that can quantitatively evaluate the MS lesions with respect to degrees of demyelination and axonal damage and/or loss. With the current lack of sensitive diagnostic imaging for grading cervical spinal cord (CSC) injury and repair, our UHb-rDWI can potentially serve as a powerful tool to observe cervical spinal cord once validated through animal studies. Therefore, the main objective of this study was to evaluate mouse spinal cords with and without demyelination using UHb-rDWI and immunohistochemical analyses to authenticate the reliability and reproducibility of UHb-rDWI.
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