Abstract #2805

Decline of both iron concentration and iron content within the thalamus of patients with multiple sclerosis over two years

Fahad Salman¹, Niels Bergsland^1,2, Michael G Dwyer^1,3, Bianca Weinstock-Guttman⁴, Robert Zivadinov^1,3, and Ferdinand Schweser^1,3

¹Buffalo Neuroimaging Analysis Center, Department of Neurology at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ²IRCCS, Fondazione Don Carlo Gnocchi ONLUS, Milan, Italy, ³Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States, ⁴Jacobs Multiple Sclerosis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States

This study investigates the temporal evolution of iron content and concentration in thalamic nuclei of patients with multiple sclerosis over two years. Both metrics declined significantly relative to controls in the pulvinar. Pulvinar iron may potentially serve as an imaging biomarker for oligodendroglial vitality in MS.

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